Pap Smear · Pathology

What is the primary advantage of Liquid-Based Cytology (LBC) over the conventional Pap smear?

  1. It is significantly cheaper and more cost-effective to perform
  2. It enables ancillary HPV DNA testing from the residual sample vial
  3. It eliminates the need for any microscopic examination of the cells
  4. It can be performed without requiring a full speculum examination
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Correct answer: It enables ancillary HPV DNA testing from the residual sample vial

LBC involves rinsing the collection device into a preservative vial, which reduces obscuring material like blood or mucus and creates a thin layer of cells. Crucially, the residual liquid can be used for molecular testing, such as high-risk HPV DNA assays.

Difficulty: Medium Question 8 of 20

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