Urinalysis · Pathology

What is the clinical significance of finding 'glitter cells' in a urine microscopic examination?

  1. They are pathognomonic for renal cell carcinoma
  2. They are neutrophils in hypotonic urine seen in pyelonephritis
  3. They are a sign of significant lipiduria in nephrotic syndrome
  4. They typically indicate vaginal or fecal specimen contamination
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Correct answer: They are neutrophils in hypotonic urine seen in pyelonephritis

Glitter cells are neutrophils that exhibit Brownian movement of their granules in hypotonic urine (low specific gravity). While not exclusive to one disease, they are traditionally associated with pyelonephritis or lower urinary tract infections.

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