Semen Analysis · Pathology

The presence of a 'cytoplasmic droplet' on the midpiece of a sperm cell is a sign of:

  1. Genetic mutation
  2. Immaturity of the sperm
  3. Viral infection
  4. Normal variation in all fertile men
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Correct answer: Immaturity of the sperm

As sperm mature in the epididymis, they normally shed their excess cytoplasm. The presence of a large cytoplasmic droplet (greater than one-third the size of the sperm head) is considered a morphological defect indicating incomplete maturation.

Difficulty: Medium Question 15 of 20

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