Hypertension Pathology · Pathology

Conn Syndrome (Primary Aldosteronism) causes secondary hypertension through which mechanism?

  1. Direct release of epinephrine from the adrenal medulla
  2. Excess sodium retention and potassium excretion
  3. Excess cortisol production causing vessel sensitization
  4. Renin-angiotensin system activation
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Correct answer: Excess sodium retention and potassium excretion

Primary aldosteronism is characterized by autonomous secretion of aldosterone (usually from an adrenal adenoma). This leads to increased sodium retention, water expansion, and hypertension, typically accompanied by hypokalemia and low plasma renin.

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