Pseudostratified Epithelium · Histology

What is the clinical significance of 'Squamous Metaplasia' in the trachea of chronic smokers?

  1. The epithelium becomes thicker and more efficient at moving mucus
  2. Basal cells stop dividing
  3. Cilia grow longer to compensate for smoke inhalation
  4. Ciliated epithelium is replaced by stratified squamous epithelium
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Correct answer: Ciliated epithelium is replaced by stratified squamous epithelium

Chronic irritation from smoke causes the delicate respiratory epithelium to transform into a more durable stratified squamous epithelium. While more resistant to physical damage, this new tissue lacks cilia and goblet cells, impairing mucus clearance.

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