Dense Irregular Connective Tissue · Histology

Under high magnification, fibroblasts in dense irregular connective tissue appear as:

  1. Flattened or spindle-shaped nuclei between collagen bundles
  2. Large, round cells with prominent cytoplasmic granules
  3. Squamous cells with distinct cell borders and visible nuclei
  4. Multinucleated giant cells with fused cytoplasm
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Correct answer: Flattened or spindle-shaped nuclei between collagen bundles

Because the collagen fibers are so dense, the fibroblasts have very little space. Their nuclei appear elongated and dark-staining, often with very little visible cytoplasm in standard preparations.

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