Dense Irregular Connective Tissue · Histology

During the transition from granulation tissue to a mature scar, the tissue becomes:

  1. Less cellular, less vascular, with denser irregular collagen
  2. Increasingly cellular with more blood vessel formation
  3. Gradually transformed into hyaline cartilage tissue
  4. Structurally identical to the original loose connective tissue
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Correct answer: Less cellular, less vascular, with denser irregular collagen

As a wound matures, the temporary granulation tissue is replaced by dense irregular collagen bundles. This scar tissue has fewer blood vessels and cells than the original tissue, making it tougher but less metabolically active.

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