Dense Irregular Connective Tissue · Histology

In an H&E stained slide of the dermis, the collagen bundles of dense irregular connective tissue appear:

  1. Basophilic (blue/purple) and thin
  2. Translucent and glassy
  3. Black and branching
  4. Eosinophilic (pink/red) and thick
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Correct answer: Eosinophilic (pink/red) and thick

Collagen is an acidophilic protein that binds to the acidic dye eosin. Consequently, the thick bundles characteristic of dense irregular tissue appear bright pink or red under the microscope.

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