Adipocytes · Histology

Which protein, unique to the inner mitochondrial membrane of brown adipocytes, allows for heat generation?

  1. Leptin
  2. Adiponectin
  3. Thermogenin (UCP-1)
  4. Cytochrome c oxidase
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Correct answer: Thermogenin (UCP-1)

Thermogenin, or Uncoupling Protein 1 (UCP-1), allows protons to leak across the inner mitochondrial membrane. This bypasses ATP synthase, dissipating the proton gradient energy as heat.

Difficulty: Medium Question 4 of 20

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