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Interstitial Growth · Histology

In adult humans, interstitial growth is significantly limited because:

  1. The matrix becomes too rigid for cells to divide and move apart.
  2. Chondrocytes permanently lose their nuclei and can no longer divide.
  3. All remaining cartilage is eventually replaced by ossified bone tissue.
  4. The blood supply to the cartilage increases with age.
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Correct answer: The matrix becomes too rigid for cells to divide and move apart.

As cartilage ages, the matrix becomes less hydrated and more cross-linked. This increased rigidity inhibits the ability of chondrocytes to divide and move apart, effectively ending significant interstitial growth.

Difficulty: Medium Question 15 of 20

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