Cartilage Degeneration · Histology

Which cartilage component primarily deteriorates during degeneration?

  1. Proteoglycan-rich matrix
  2. Perichondrial blood supply
  3. Periosteal nerve fibers
  4. Subchondral bone trabeculae
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Correct answer: Proteoglycan-rich matrix

Degeneration often involves the loss of proteoglycans and breakdown of the extracellular matrix. This reduces cartilage resilience and ability to withstand compression.

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