In Infectious Mononucleosis, which histological feature is classically seen in a peripheral blood smear?
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Correct answer: Atypical lymphocytes (Downey cells)
Infectious mononucleosis, typically caused by the Epstein-Barr virus, triggers a T-cell response. These activated T-lymphocytes appear 'atypical' with larger, irregularly shaped nuclei and foamy cytoplasm.
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