Polyploidy · Botany

How does colchicine induce chromosome doubling?

  1. It permanently breaks down and completely dissolves all plant cell walls
  2. It converts genomic DNA sequences directly into RNA molecules
  3. It stops photosynthesis by permanently destroying all chlorophyll
  4. It inhibits spindle fiber formation so chromosomes cannot separate
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Correct answer: It inhibits spindle fiber formation so chromosomes cannot separate

Colchicine interferes with microtubule formation, so spindle fibers cannot function normally. As a result, replicated chromosomes may remain in the same cell, producing a doubled chromosome number.

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