Which histone is primarily responsible for linking adjacent nucleosomes?
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Correct answer: H1, which binds linker DNA between nucleosomes
Histone H1 (the linker histone) binds to the DNA that enters and exits the nucleosome core (linker DNA). It compacts the nucleosome array into a 30 nm chromatin fiber, stabilizing higher-order chromatin folding. The four core histones (H2A, H2B, H3, H4) form the octamer around which the DNA wraps.
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