Which type of bond links nucleotides in a nucleic acid strand?
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Correct answer: Phosphodiester bond
Adjacent nucleotides in a nucleic acid strand are covalently joined by phosphodiester bonds: each phosphate group bridges the 3'-hydroxyl of one sugar to the 5'-carbon of the next, forming the continuous sugar-phosphate backbone. Hydrogen bonds, in contrast, hold the two strands of the double helix together through base pairing.
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