Immunoglobulins and Antigens · Zoology

The Fc region of an antibody is primarily involved in:

  1. Antigen binding at the paratope site
  2. Complement activation and effector cell interaction
  3. Determining antibody specificity through hypervariable loop conformation
  4. Formation of the variable domains via VDJ recombination
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Correct answer: Complement activation and effector cell interaction

The Fc region interacts with Fc receptors on immune cells (macrophages, NK cells) and with complement protein C1q. It mediates effector functions such as opsonization, antibody-dependent cellular cytotoxicity (ADCC), and complement activation.

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