Acid-base homeostasis · USMLE Step 1

Which of the following is the fastest acting mechanism to buffer acute changes in blood pH?

  1. Renal compensation
  2. Respiratory compensation
  3. Chemical buffer systems
  4. Bone buffering
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Correct answer: Chemical buffer systems

Chemical buffer systems (like bicarbonate, phosphate, protein buffers) act within seconds to minimize pH changes, preceding respiratory or renal compensation.

Difficulty: Medium Question 7 of 19

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