Drug Classes and Mechanisms · USMLE Step 1

Which antihypertensive class is most appropriate in a patient with concurrent heart failure with reduced ejection fraction (HFrEF)?

  1. Calcium channel blocker
  2. ACE inhibitor
  3. Loop diuretic
  4. Alpha-1 blocker
Show answer and explanation

Correct answer: ACE inhibitor

ACE inhibitors improve survival and reduce remodeling in HFrEF by decreasing afterload, preload, and pathological neurohormonal activation.

Difficulty: Medium Question 16 of 19

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