Antimicrobials and Resistance · USMLE Step 1

A patient with MRSA is started on daptomycin. Why should lung infections not be treated with this drug?

  1. Poor penetration into lung tissue
  2. Inactivation by pulmonary surfactant
  3. Rapid development of resistance
  4. Risk of pulmonary fibrosis
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Correct answer: Inactivation by pulmonary surfactant

Daptomycin is bound and inactivated by surfactant, making it ineffective for pneumonia.

Difficulty: Medium Question 16 of 20

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