Microbial diagnostics · USMLE Step 1

A biopsy from a patient with suspected herpesvirus infection shows multinucleated giant cells. What diagnostic test corresponds to this finding?

  1. Tzanck smear
  2. Gomori silver stain
  3. India ink preparation
  4. Cold agglutinin test
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Correct answer: Tzanck smear

Tzanck smear reveals multinucleated giant cells in herpes infections. It is rapid but not specific for viral type.

Difficulty: Medium Question 19 of 20

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