Tissue types and function · USMLE Step 1

Which tissue type is least likely to regenerate capacity in an adult human with significant injury, contributing to scar formation rather than full structural restoration?

  1. Epithelial tissue
  2. Connective tissue (dense) — tendon/ligament
  3. Smooth muscle tissue of gut
  4. Nervous tissue (central nervous system neurons)
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Correct answer: Nervous tissue (central nervous system neurons)

Neurons in the central nervous system (nervous tissue) have very limited regenerative capacity; damage often leads to permanent loss or scarring because neurons seldom proliferate to replace lost cells. The other tissues have at least some regenerative or reparative potential.

Difficulty: Medium Question 12 of 22

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