Membrane Transport Mechanisms · USMLE Step 1

Which of the following molecules would most likely cross a cell membrane by passive diffusion rather than facilitated diffusion or active transport?

  1. Glucose
  2. Sodium ion (Na⁺)
  3. O₂ (oxygen) gas
  4. Amino acid
Show answer and explanation

Correct answer: O₂ (oxygen) gas

Oxygen is a small nonpolar gas that can dissolve in the hydrophobic core of the membrane and cross by simple diffusion; charged ions and large polar molecules generally require transport proteins.

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