Which of the following conditions would favor passive leakage of a hydrophobic drug across cell membranes into cells?
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Correct answer: High lipid solubility and no charge on the drug molecule
Hydrophobic, uncharged, lipid-soluble molecules diffuse more readily through the lipid bilayer by simple diffusion; this property enhances passive membrane permeation. Other features (size, polarity, charge) would hinder membrane passage.
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