A neonate presents with polydactyly, microcephaly, and congenital heart disease. Genetic testing shows meiotic nondisjunction. Which trisomy is most likely?
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Correct answer: Trisomy 13
Trisomy 13 (Patau syndrome) commonly presents with polydactyly and severe craniofacial anomalies. It is caused by meiotic nondisjunction. The other trisomies have different clinical patterns.
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