Respiratory adaptations · Physiology

During acclimatization to high altitude, the oxygen–hemoglobin dissociation curve shifts:

  1. To the left due to respiratory alkalosis
  2. To the right due to increased 2,3-BPG
  3. Downward due to reduced hemoglobin
  4. Upward due to increased carbon dioxide
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Correct answer: To the right due to increased 2,3-BPG

Increased 2,3-BPG levels shift the curve to the right. This facilitates oxygen unloading to tissues.

Difficulty: Medium Question 3 of 20

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