Control of respiration · Physiology

What is the effect of sleep on the CO2 response curve of the respiratory system?

  1. The curve shifts to the left, showing increased sensitivity
  2. The curve shifts right, showing decreased sensitivity
  3. The slope of the response curve becomes steeper
  4. Sleep has essentially no effect on CO2 sensitivity
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Correct answer: The curve shifts right, showing decreased sensitivity

During sleep, the respiratory center becomes less sensitive to CO2, causing the arterial PCO2 to rise slightly (about 3-4 mmHg). This rightward shift is why breathing is more likely to become irregular or periodic during sleep.

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