Neuromuscular disorders · Physiology

Which feature distinguishes Lambert-Eaton syndrome from myasthenia gravis?

  1. Presence of prominent muscle weakness at rest
  2. Frequent association with autoimmune thyroid disease
  3. Improvement of strength with repeated activity
  4. Predominant involvement of ocular muscles
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Correct answer: Improvement of strength with repeated activity

In Lambert-Eaton syndrome, muscle strength improves with brief repeated use as calcium accumulates and boosts acetylcholine release. This contrasts with myasthenia gravis, where activity worsens weakness.

Difficulty: Medium Question 5 of 20

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