Menstrual Cycle and Spermatogenesis · Physiology

The 'LH surge' that triggers ovulation is primarily caused by which physiological event?

  1. A rapid drop in progesterone levels
  2. Negative feedback from low levels of estrogen
  3. Positive feedback from high levels of estrogen
  4. The secretion of GnRH from the posterior pituitary
Show answer and explanation

Correct answer: Positive feedback from high levels of estrogen

When estrogen levels reach a high threshold for approximately 36 to 48 hours, the feedback loop switches from negative to positive. This results in a massive release of LH, leading to the rupture of the dominant follicle.

Difficulty: Medium Question 22 of 40

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