Which inflammatory mediators are targeted by montelukast and zafirlukast?
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Correct answer: Cysteinyl leukotrienes
Montelukast and zafirlukast block the CysLT1 receptor for cysteinyl leukotrienes (LTC4, LTD4, LTE4), which drive bronchoconstriction, mucus secretion and eosinophilic inflammation in asthma.
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