Stimulants · Pharmacology

Methylphenidate primarily acts by:

  1. Promoting serotonin release from vesicles
  2. Blocking dopamine and norepinephrine reuptake
  3. Enhancing GABA-mediated inhibitory transmission
  4. Inhibiting acetylcholinesterase in the synapse
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Correct answer: Blocking dopamine and norepinephrine reuptake

Methylphenidate inhibits reuptake of dopamine and norepinephrine in the synaptic cleft. This increases their availability and enhances attention.

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