Skin Pathology · Pathology

Which epidermal layer is primarily responsible for barrier function in normal skin?

  1. Stratum basale
  2. Stratum spinosum
  3. Stratum granulosum
  4. Stratum corneum
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Correct answer: Stratum corneum

The stratum corneum provides the primary barrier function of the skin. It consists of keratinized cells embedded in a lipid matrix that prevents water loss and pathogen entry.

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