Precision Medicine · Pathology

Which biomarker is commonly tested to determine eligibility for anti-EGFR therapy in colorectal cancer?

  1. BRCA1 germline mutation
  2. KRAS activating mutation
  3. TP53 loss-of-function deletion
  4. MYC oncogene amplification
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Correct answer: KRAS activating mutation

KRAS mutation testing is essential before anti-EGFR therapy in colorectal cancer. Patients with KRAS mutations do not benefit from these targeted therapies.

Difficulty: Medium Question 7 of 20

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