Overfixation of tissue in formalin may lead to:
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Correct answer: Loss of antigenicity
Prolonged fixation can mask antigenic sites, reducing immunohistochemical staining sensitivity. It may also cause excessive cross-linking of proteins.
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More Artifacts in Histology questions
- Which artifact is commonly seen when tissue dries out before fixation?
- Crush artifact is most frequently associated with:
- Floaters in histology slides refer to:
- Incomplete deparaffinization before staining may result in:
- Which artifact is most likely due to overheating during paraffin embedding?
- Stain precipitate artifact appears as: