Which of the following is a cytoplasmic feature of cells undergoing irreversible injury?
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Correct answer: Increased eosinophilia
Necrotic cells show increased eosinophilia (pinker stain) on H&E sections. This is due to the loss of cytoplasmic RNA (which binds the blue dye, hematoxylin) and the increased binding of eosin to denatured cytoplasmic proteins.
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