Which enzyme is responsible for the activation of 'executioner' caspases via the extrinsic (death receptor) pathway?
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Correct answer: Caspase-8
While Caspase-3 is the primary executioner, it is activated by initiator caspases. Caspase-8 is the initiator for the extrinsic (death receptor) pathway, while Caspase-9 is the initiator for the intrinsic (mitochondrial) pathway.
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