Loss of heterozygosity in MEN1 tumorigenesis supports which model of cancer development?
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Correct answer: Two-hit hypothesis
MEN1 follows the two-hit hypothesis for tumor suppressor genes. An inherited germline mutation is followed by somatic loss of the remaining normal allele.
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More Multiple Endocrine Neoplasia questions
- Which hormone excess is commonly associated with MEN1-related pancreatic tumors?
- Which feature is most typical of MEN2A-associated hyperparathyroidism?
- Genetic testing for RET mutations is most important in families with which tumor history?
- Multiple Endocrine Neoplasia type 1 (MEN1) is caused by mutations in which gene?
- Which combination of tumors is classically associated with MEN1?
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