Neonatal Transition and Newborn Care · NCLEX Exam

What mechanism leads to the functional closure of the ductus arteriosus in a healthy term neonate?

  1. A fall in arterial oxygen tension after birth
  2. A rise in circulating prostaglandin E2 levels
  3. Rising arterial oxygen tension with falling prostaglandins
  4. Persistence of fetal lung fluid in the alveoli
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Correct answer: Rising arterial oxygen tension with falling prostaglandins

Increased oxygen and decreased prostaglandins lead to vasoconstriction of the ductus arteriosus and eventual functional closure.

Difficulty: Medium Question 15 of 25

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