Neuromuscular Disorders · NCLEX Exam

In patients with multiple sclerosis (MS), heat intolerance may worsen symptoms due to which phenomenon?

  1. Increased conduction speed in demyelinated nerves
  2. Demyelinated axons conduct poorly as temperature rises (Uhthoff’s phenomenon)
  3. Heat selectively repairs the damaged myelin sheath
  4. Heat reliably improves nerve conduction in every patient
Show answer and explanation

Correct answer: Demyelinated axons conduct poorly as temperature rises (Uhthoff’s phenomenon)

In MS, heat can worsen symptoms due to demyelinated axons being vulnerable to increased temperature, known as Uhthoff’s sign.

Difficulty: Medium Question 10 of 12

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