Endocrine Tumors · NCLEX Exam

Which genetic mutation is closely associated with medullary thyroid carcinoma and pheochromocytoma in the context of MEN2?

  1. RET proto-oncogene mutation
  2. BRAF V600E activating mutation
  3. TP53 tumour suppressor mutation
  4. BRCA1 germline mutation
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Correct answer: RET proto-oncogene mutation

The RET proto-oncogene mutation is associated with MEN2 syndromes which include medullary thyroid carcinoma and pheochromocytoma.

Difficulty: Medium Question 16 of 20

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