Tumor Lysis Syndrome and Oncologic Emergencies · NCLEX Exam

Why does hyperphosphatemia in Tumor Lysis Syndrome cause hypocalcemia?

  1. Phosphate stimulates PTH release and lowers calcium
  2. Calcium shifts intracellularly during cell lysis
  3. Calcium and phosphate precipitate in renal tubules
  4. Calcium binds albumin and becomes biologically inactive
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Correct answer: Calcium and phosphate precipitate in renal tubules

Elevated phosphate binds to calcium, leading to formation of calcium-phosphate precipitates in kidneys, causing hypocalcemia.

Difficulty: Hard Question 15 of 20

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