Immunotherapy and Targeted Therapy · NCLEX Exam

A small-molecule targeted therapy differs from a monoclonal antibody because:

  1. Small molecules cannot enter cells and act only outside them
  2. Small molecules are large proteins binding extracellular antigens
  3. Small molecules enter cells and inhibit intracellular targets
  4. Small molecules are used only for infections, not for cancer
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Correct answer: Small molecules enter cells and inhibit intracellular targets

Small-molecule targeted therapies are designed to penetrate cells and inhibit intracellular proteins or signalling pathways; monoclonal antibodies usually target extracellular or cell-surface molecules.

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