Mitosis: Stages and Significance · NCERT Biology

Which structure disappears first during prophase?

  1. Nuclear membrane
  2. Nucleolus
  3. Chromosome threads
  4. Centriole pairs
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Correct answer: Nucleolus

During prophase, the nucleolus is the first structure to disappear as rRNA synthesis ceases and the cell reorganizes for division. The nuclear envelope breaks down later, at the transition to prometaphase.

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