Muscle Fibers · Histology

The diameter of a skeletal muscle fiber increases during weight training primarily through:

  1. Hyperplasia (increased total fiber number)
  2. Hypertrophy (increased myofibril number)
  3. Accumulation of extracellular fluid
  4. Increased thickness of the epimysium
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Correct answer: Hypertrophy (increased myofibril number)

Adult skeletal muscle fibers generally do not divide. Instead, they grow larger (hypertrophy) by synthesizing more actin and myosin and increasing the number of myofibrils, usually in response to increased mechanical load.

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