Periosteum · Histology

In the event of a bone fracture, the periosteum contributes to healing by:

  1. Forming a repair callus from its osteoprogenitor cells
  2. Activating osteoclasts to resorb damaged bone fragments
  3. Secreting proteoglycans to cushion the fracture site
  4. Triggering cartilage hypertrophy in the medullary canal
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Correct answer: Forming a repair callus from its osteoprogenitor cells

Upon injury, osteoprogenitor cells in the periosteum rapidly divide and differentiate into osteoblasts and chondroblasts. These cells form the external callus that stabilizes the fracture during the repair process.

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