Deficiency in the enzyme NADPH oxidase leads to which clinical condition?
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Correct answer: Chronic Granulomatous Disease
CGD is a genetic disorder where neutrophils can ingest bacteria but cannot produce the respiratory burst to kill them. This leads to the formation of persistent granulomas as the body tries to wall off the chronic infections.
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More Neutrophils questions
- What is the typical lifespan of a mature neutrophil in the peripheral circulation?
- Which morphological feature is characteristic of a mature neutrophil on a peripheral blood smear?
- The primary (azurophilic) granules of neutrophils are specialized lysosomes that contain which of the following?
- What is the primary function of the 'specific' (secondary) granules in neutrophils?
- The 'Barr body' sometimes seen in the neutrophils of females represents which of the following?
- What is the process by which neutrophils migrate out of the blood vessels and into the connective tissue?